Reproductive semi-cloning respecting biparental origin. A biologically unsound principle.
نویسندگان
چکیده
The original debate article proposed the use of "semi-cloning" as a viable method for assisted reproduction. This debate counters the proposal as being biologically unsound. Given the fundamental limitations of chromosomal segregation and genomic imprinting, the notion of using the MII oocyte to drive haploidization of a somatic cell genome and thereby obtain a substitute for authentic gametes is ill-conceived and untenable.
منابع مشابه
Reproductive semi-cloning respecting biparental embryo origin: embryos from syngamy between a gamete and a haploidized somatic cell.
Embryos formed by somatic cell nuclear transfer to enucleated oocytes (cloning) have given rise to viable offspring in several mammalian species. The possibility of future application of this technique to human assisted reproduction (reproductive cloning) has been widely debated. On this background there is current discussion of the potential for a cloning-derived technique, which aims at synga...
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ورودعنوان ژورنال:
- Human reproduction
دوره 18 3 شماره
صفحات -
تاریخ انتشار 2003